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Synthesis and in vitro Cytotoxicity Studies of
Novel Triazolo[4,3-b]pyridazinones
E.M. Rakiba,* , S.
Abourichaa,b, A. Hanniouia, N. Benchatb, L.
Ait M�barekc and A. Zyadc
a Laboratory of Organic and
Analytical Chemistry, Faculty of Sciences and Techniques, Beni-Mellal,
Morocco
bDepartment of Chemistry, Faculty of Sciences, University
Mohammed I, Oujda, Morocco
cLaboratory of Immunological, Biochemical and Molecular Biology,
Faculty of Sciences and Techniques, Beni-Mellal, Morocco
(Received 10 March 2006, Accepted 8 June 2006)
New triazolo[4,3-b]pyridazinones
were synthesized and evaluated for their potential in vitro cytotoxic
antitumor properties. The compounds were prepared by 1,3-dipolar
cycloaddition of pyridazin-3-ones with N-aryl-C-ethoxycarbonylnitrile
imines, generated in situ from ethylhydrazono-a -bromoglyoxylates.
The peri- and regioselectivity of the reaction were ascertained by 1H
and 13C NMR spectroscopy of the cycloadducts.
Keywords:
Triazolo[4,3-b]pyridazinones, Cycloaddition, Cytotoxicity, Hep cells |
