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Wet Silica-Supported Permanganate: A Mild and
Inexpensive Reagent for Highly Enantiomeric Purity Conversion of α-Sulfinyl
Oximes and α-Sulfinyl Hydrazones to α-Keto Sulfoxides
A.R. Hajipour*,a,b and A.E. Ruohoa
a
Department of Pharmacology, University of
Wisconsin, Medical School,1300 University Avenue, Madison,WI
53706-1532, USA b
Pharmaceutical Research Laboratory, College of
Chemistry, Isfahan University of Technology, Isfahan
84156, IR Iran
(Received 27 September2003, Accepted 29 May
2004)
Wet silica-supported
potassium permanganate was used as an inexpensive and efficient reagent for
conversion of α-sulfinyl oximes 1 and α-sulfinyl hydrazones 2 to
the corresponding α-keto sulfoxides (3) in high yields and high
enantiomeric purity under solvent-free conditions.
Keywords:
Deprotection, Wet silica, Solvent-free
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