One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (Thiones) Promoted by Nano-BF₃.SiO₂

B.F. Mirjalili^a,, A. Bamoniri^b and A. Akbari^a*

^aDepartment of Chemistry, College of Science, Yazd University, Yazd, P.O. Box 89195-741, I. R. Iran
^bDepartment of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran

3,4-Dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thione were synthesized under solvent free condition in the presence of nano-silica supported boron trifluoride (nano-BF₃.SiO₂). The reactions were carried out at 80 °C for 15 min under solvent free condition. This methods have some advantages such as good to excellent yield, mild reaction condition, ease of operation and workup, short reaction time and high product purity.

Keywords: Nano-BF₃_˙SiO₂, Biginelli reaction, Aldehyde, 3,4-Dihydropyrimidin-2(1H)-ones, 3,4-Dihydropyrimidin-2(1H)-thiones

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (Thiones) Promoted by Nano-BF3.SiO2

B.F. Mirjalilia,*, A. Bamonirib and A. Akbaria

aDepartment of Chemistry, College of Science, Yazd University, Yazd, P.O. Box 89195-741, I. R. Iran bDepartment of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones (Thiones) Promoted by Nano-BF₃.SiO₂

B.F. Mirjalili^a,, A. Bamoniri^b and A. Akbari^a*

^aDepartment of Chemistry, College of Science, Yazd University, Yazd, P.O. Box 89195-741, I. R. Iran
^bDepartment of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran