Current location: JICS Archive > Vol. 8 > No. 4 > Articles : 29
The Regioselective Synthesis of Bromochlorins Related to Chlorophyll-a from Methyl Pheophorbide-a
J.J. Wang*, J.Z. Li and F.G. Li
Science and Engineering College of Chemistry and Biology, Yantai University, Yantai 264005, P. R. China
An efficient methodology has been developed for the regioselective synthesis of brominated chlorins related to chlorophyll-a from methyl pheophorbide-a. Several regioselective bromination reactions were accomplished by some particular reactionconditions and a series of conversion of functional group from methyl pheophorbide-a to synthesize mono-, bis- and tri-brominated chlorines. The possible mechanisms for the debromination were tentatively proposed and the structures of all new chlorins were characterized by elemental analysis, IR, UV-Vis and 1H NMR spectra.
Keywords: Chlorophyll-a, Chlorin, Bromination, Regioselective synthesis, Photodynamic therapy (PDT)
