Current location: JICS Archive > Vol. 8 > No. 4 > Articles : 28

Synthesis of Two New Heterocyclic Systems: Furo[3',2':5,6]pyrimido[2,1-c][1,2,4]triazines and Furo[3,2-e][1,2,3,4]tetrazolo[1,5-a]pyrimidine

M. Rahimizadeh^a,*, M. Bakavoli^a, Z. Gordi^a,b and S.M. Seyedi^a

^aDepartment of Chemistry, Ferdowsi University of Mashhad, Mashhad 91775-1436, Iran
^bDepartment of Chemistry, Payame Noor University (PNU), Torbat-e-Heydarieh, Iran

     Two novel heterocyclic triazines and tetrazole systems were synthesized through cyclization of 2-hydrazino-furo[2,3-d]pyrimidine with α-haloketones and nitrous acid respectively in high yields. The starting 2-hydrazino-pyrimidine was synthesized from 4-imino-3,6-diphenyl-furo[2,3-d]pyrimidine-2(1H)-thione by methylation and subsequent nucleophilic displacement of methylthio group with hydrazine hydrate.

Keywords: Furo[2,3-d]pyrimidine, α-Haloketones, Triazines, Tetrazole