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NaI Readily Mediated Oxidative Aromatization of Hantzsch 1,4-Dihydropyridines with Hydrogen Peroxide at Room Temperature: A Green Procedure

D. Shahabi, M.A. Amrollahi* and A.A. Jafari

Department of Chemistry, Faculty of Science, Yazd University, Yazd 89195-741, Iran

      The oxidative conversion of 1,4-dihydropyridines to give the corresponding pyridine derivatives in excellent yields was easily effected using the catalytic amount of NaI in combination with H₂O₂ (30%) as a green external oxidant. The process is highly green wherein the solid products are easily filtered out after the addition of ice-water to the reaction mixture. This non-transition metal catalyst is cost-effective, affords simple work-up and easy separation of the product.

Keywords: 1,4-Dihydropyridines, Aromatization, H2O2, NaI, Oxidation