Current location: JICS Archive > Vol. 8 > No. 4 > Articles : 17

Efficient Microwave-Assisted Synthesis of 3-Benzothiazolo and 3-Benzothiazolino Coumarin Derivatives Catalyzed by Heteropoly Acids

M. Khoobi^a, A. Ramazani^a, A.R. Foroumadi^b, H. Hamadi^c, Z. Hojjati^a and A. Shafiee^b,*

^aChemistry Department, Zanjan University, P.O. Box 45195-313, Zanjan, Iran
^bDepartment of Medicinal Chemistry, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of  Medical Sciences, Tehran 14176, Iran
^cDepartment of Chemistry, Chamran University, Ahvaz 61357-4-3169, Iran

Heteropoly acids are reported as efficient catalysts for the microwave-assisted synthesis of 3-benzothiazolo and 3-benzothiazolino coumarin from o-aminothiophenol derivatives with 3-acetly and 3-cyanochromen-2-one in good to excellent isolated yields (73-95%). This study suggests new techniques for the synthesis of chromene derivatives using an inexpensive and easily available catalyst, a simple procedure, short reaction time, and good to excellent yields of the products.

Keywords: o-Aminothiophenol, 3-Benzothiazolino coumarin, 3-Benzothiazolo coumarin, Heteropoly acid