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ZnO Nanoparticles Catalyzed Efficient One-Pot Three-Component Synthesis of 2,3-Disubstituted Quinalolin-4(1H)-ones under Solvent-Free Conditions

I. Yavari* and S. Beheshti

Department of Chemistry, Tarbiat Modares University, P. O. Box: 14115-175, Tehran, Iran

      ZnO nanoparticles were prepared and applied as a favorable catalyst in three-component one-pot cyclocondensation reaction of isatoic anhydride with amines and aldehydes to afford the corresponding 2,3-disubstituted quinalolin-4(1H)-ones in good yields. Reactions occurred under solvent-free conditions in high atom economy.

Keywords: ZnO nanoparticles, Isatoic anhydride, Quinazolinone, Solvent-free