SbCl₅.SiO₂: an Efficient Alternative for One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles in Solvent or under Solvent-Free Condition

B. Sadeghi^a,, B.B.F. Mirjalili^b, S. Bidaki^a and M. Ghasemkhani^a*

^aDepartment of Chemistry, Islamic Azad University, Yazd Branch, P.O. Box 89195-155, Yazd, Iran
^bDepartment of Chemistry, College of Science, Yazd University, P.O. Box 89195-741, Yazd, Iran

In a one-pot four-component reaction, an aldehyde, an amine, benzil and ammonium acetate were condensed for the synthesis of 1,2,4,5-tetrasubstituted imidazoles in the presence of silica supported antimony pentachloride (SbCl₅.SiO₂) in improved yields. The catalyst is recoverable by simple filtration and can be used in the subsequent reactions.

Keywords: 1,2,4,5-Tetrasubstituted imidazoles, SbCl₅.SiO₂, Benzil, One-pot synthesis, Aldehyde

SbCl5.SiO2: an Efficient Alternative for One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles in Solvent or under Solvent-Free Condition

B. Sadeghia,*, B.B.F. Mirjalilib, S. Bidakia and M. Ghasemkhania

aDepartment of Chemistry, Islamic Azad University, Yazd Branch, P.O. Box 89195-155, Yazd, Iran bDepartment of Chemistry, College of Science, Yazd University, P.O. Box 89195-741, Yazd, Iran

SbCl₅.SiO₂: an Efficient Alternative for One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles in Solvent or under Solvent-Free Condition

B. Sadeghi^a,, B.B.F. Mirjalili^b, S. Bidaki^a and M. Ghasemkhani^a*

^aDepartment of Chemistry, Islamic Azad University, Yazd Branch, P.O. Box 89195-155, Yazd, Iran
^bDepartment of Chemistry, College of Science, Yazd University, P.O. Box 89195-741, Yazd, Iran