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Catalytic Multicomponent Reactions Based on Isocyanides

M.M. Heravi* and S. Moghimi

Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran

Due to their versatility and diversity, catalytic multi-component isocyanide-based reactions (IMCR), are very interesting and important. Isocyano group is a unique functional group due to its reactivity toward electerophiles and nucleophiles at the same atom. It participates in many multi-component reactions along with various catalysts which dramatically improve reaction conditions for the achievement of better yields, milder and benign reaction condition and in some cases better stereoselectivities. In this review, we wish to disclose the recent applications of metal, basic, acidic and many other catalytic systems in the IMCRs. In supplementary section we also updated our review with all related publications in 2010.

Keywords: Isocyanide-based reaction, Lewis acids, Bronsted acids, Ugi reaction