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An Efficient One-Pot Synthesis of Carbazates and Dithiocarbazates through the Corresponding Alcohols Using Mitsunobu’s Reagent

A.K. Chaturvedi^a,  D. Chaturvedi^b,†,*, N. Mishra^a and V. Mishra^a

^aSynthetic Research Laboratory, Department of Chemistry, B. S. A. P. G. College, Mathura-281004, U. P., India
^bBio-Organic Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi-180001, J. & K., India
^†Present address for correspondence: Natural Products Chemistry Division, North-East Institute of Science and Technology (CSIR), Jorhat-785006, Assam, India

     A novel Mitsunobu-based protocol has been developed for the synthesis of carbazates and dithiocarbazates through the variety of corresponding primary, secondary and tertiary alcohols and various kinds of substituted hydrazines using Mitsunobu’s reagent and CO₂/CS₂ system, in good to excellent yields.

Keywords: Alcohols, Carbon dioxide, Carbon Disulfide, Mitsunobu’s reagent, Carbazates, Dithiocarbazates