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Amino-Functionalized MCM-41 Base-Catalyzed One-Pot Synthesis of 2-Amino-5,6-dihydropyrimidin-4(3H)-ones

M. Mirza-Aghayan^a,*, T. Baie Lashaki^a, M. Rahimifard^a, R. Boukherroub^b and A.A. Tarlani^a

^aChemistry and Chemical Engineering Research Center of Iran (CCERCI), P. O. BOX 14335-186, Tehran, Iran
^bInstitut de Recherche Interdisciplinaire (IRI, USR 3078), Parc de la Haute Borne, 50 Avenue de Halley - BP 70478, 59658 Villeneuve d'Ascq and Institut d’Electronique, de Microélectronique et de Nanotechnologie (IEMN, UMR 8520), Cité Scientifique, Avenue Poincaré - B.P 60069, 59652 Villeneuve d’Ascq, France

A simple and efficient one-pot method for the preparation of 2-amino-5,6-dihydropyrimidin-4(3H)-one from the cyclocondensation of Meldrum's acid, aldehydes and guanidinium carbonate using a catalytic amount of amino-functionalized MCM-41 is described. This efficient technique has the advantage of giving 2-NH₂-DHPM building blocks using a base catalyst in good to high yields, being completed in short reaction times and offering a simple product isolation procedure.

Keywords: 2-Amino-5,6-dihydropyrimidin-4(3H)-one, Guanidinium carbonate, 2-NH₂-DHPM building blocks, Base catalyst, Amino-functionalized MCM-41