J. Iran. Chem. Soc., Vol. 7, No. 2 June 2010, pp.318~321.
Current location: JICS Archive > Vol. 7 > No. 2 > Articles : 3
Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Nafion-H Under Ultrasound Irradiation and Solvent-Free Conditions
Q. Wang and W. Pei
College of Chemical Engineering and Materials, Zhejiang University of Technology, Hangzhou 310014, China
A novel synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by one-pot cyclocondensation of aldehydes, 1,3-dicarbonyl compounds and urea or thiourea using nafion-H as the catalyst under ultrasound irradiation and solvent-free conditions was developed. Compared with the classical Biginelli reactions, this method consistently enjoys the advantages of mild reaction conditions, excellent yields, easy work up and short reaction time.
Keywords: One-pot, Nafion-H, Biginelli condensation, Ultrasound irradiation, Solvent-free
