Enantioselective Addition of Diethylzinc to Aryl Aldehydes Catalyzed by Novel Chiral Imino Alcohol Ligands

P. Salehi^a,, M. Dabiri^b,* and G. Kozehgary^b*

^aDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran 1983963113, Iran
^bDepartment of Chemistry, Faculty of Science, Shahid Beheshti University, G. C., Evin, Tehran 1983963113, Iran

The enantioselective alkylation of aryl aldehydes by diethylzinc in the presence of catalytic amounts of several novel chiral imino alcohol ligands, synthesized from the reaction of (R)-2-amino-1-butanol with aromatic aldehydes, was studied. The influence of temperature and ligand structure was investigated and enantioselectivity up to 81% was obtained.

Keywords: Imino-alcohols, Alkylation, Diethylzinc, Aryl aldehydes, Enantioselective

Enantioselective Addition of Diethylzinc to Aryl Aldehydes Catalyzed by Novel Chiral Imino Alcohol Ligands

P. Salehia,*, M. Dabirib,* and G. Kozehgaryb

aDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran 1983963113, Iran bDepartment of Chemistry, Faculty of Science, Shahid Beheshti University, G. C., Evin, Tehran 1983963113, Iran

P. Salehi^a,, M. Dabiri^b,* and G. Kozehgary^b*

^aDepartment of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran 1983963113, Iran
^bDepartment of Chemistry, Faculty of Science, Shahid Beheshti University, G. C., Evin, Tehran 1983963113, Iran