J. Iran. Chem. Soc., Vol. 7, No. 1 March 2010, pp.237~242.
Current location: JICS Archive > Vol. 7 > No. 1 > Articles : 28
One-Pot Synthesis of Dihydropyrimidinones by Dodecylphosphonic Acid as Solid Bronsted Acid Catalyst under Solvent-Free Conditions via Biginelli Condensation
S. Ghassamipour and A.R. Sardarian*
Department of Chemistry, Shiraz University, Shiraz 71454, I.R. Iran
Dodecylphosphonic acid is a solid Bronsted acid that catalyzes efficiently the preparation of dihydropyrimidinones by Biginelli condensation under solvent-free conditions. This protocol offers several advantages including high yields, short reaction times, easy work-up, and use of cheap, relatively moderate acidic and safe catalyst.
Keywords: Dihydropyrimidinone, Dodecylphosphonic acid, Solvent-free, Biginelli condensation
