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Synthesis, Characterization, Biological and Thermal Studies of Cu(II) Complexes of Salen and Tetrahedrosalen Ligands

H. Khanmohammadi^a,*, M. Salehifard^a and M.H. Abnosi^b

^aDepartment of Chemistry, Arak University, Arak 38156, Iran
^bDepartment of Biology, Arak University, Arak 38156, Iran

A series of mononuclear salen type copper(II) complexes, [CuLⁿ] (n = 1-4), and their corresponding tetrahydrosalen complexes, [CuH₂Lⁿ] (n = 1,2) were prepared by the reaction of the N₂O₂ ligands with Cu(II) ion in ethanol, where H₂L¹ = N,N-bis(3,5-di-tert-butylsalicylidene)-2,2-dimethyle-1,3-diaminopropan, H₂L² = N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-diamino-propane, H₂L³ = N,N-bis(4-methoxysalicylidene)-2,2-dimethyle-1,3-diaminopropan; H₂L⁴ = N,N-bis(4-methoxysalicylidene)-1,2-diaminopropane, H₂[H₂L¹] = N,N-bis(2-hydroxyl-3,5-di-tert-butylphenyl)-2,2-dimethyle-1,3-diaminopropan and H₂[H₂L²] = N,N-bis(2-hydroxyl-3,5-di-tert-butylphenyl)-1,2-diaminopropane. The prepared ligands and complexes were characterized by the combination of IR, UV-Vis, NMR (as far as possible), elemental and thermal analyses. All prepared compounds were also evaluated for their antibacterial (Escherichia coli and Staphylococcus aureus) and antifungal (Candida albicans) activities by the disc diffusion method. The compounds were found have no remarkable antimicrobial activities.

Keywords: Cu(II) complex, Salen, Schiff base, Thermal analysis, Biological activity