J. Iran. Chem. Soc., Vol. 6, No. 2 June 2009, pp.436~442.
Current location: JICS Archive > Vol. 6 > No. 2 > Articles : 25
One-Pot Synthesis of Pyrano[2,3-d]pyrimidinone Derivatives Catalyzed by L-Proline in Aqueous Media
M. Bararjanian, S. Balalaie*, B. Movassagh and A.M. Amani
Peptide Chemistry Research Group, K. N. Toosi University of Technology and P.O. Box 15875-4416, Tehran, Iran
An efficient protocol has been developed for the synthesis of various pyrano[2,3-d]pyrimidinones from condensation of aromatic aldehydes, malononitrile and barbituric-or thiobarbituric acid in aqueous ethanol using L-proline as a neutral bifunctional catalyst
Keywords: Aqueous media, L-Proline, Pyrano[2,3-d]pyrimidinone, Domino Knoevenagel-cyclocondensation
