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Rapid and Efficient One-Pot Synthesis of 1,4-Dihydropyridine and Polyhydroquinoline Derivatives Through the Hantzsch Four Component Condensation by Zinc Oxide

F. Matloubi Moghaddam*, H. Saeidian, Z. Mirjafary and A. Sadeghi

Laboratory of Organic Synthesis and Natural products, Department of Chemistry, Sharif University of Technology, Tehran, Iran, P. O. Box 11155-9516 Tehran, Iran

A one-pot four-component reaction of aldehydes, ethyl acetoacetate/5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate in the presence of 10 mol% of ZnO as a heterogeneous catalyst for the synthesis of corresponding 1,4-dihydropyridine and polyhydroquinoline derivatives via the Hantzsch condensation is described. The present methodology offers several advantages such as simple procedure, excellent yields, and short reaction time.

Keywords: 1,4-Dihydropyridine and polyhydroquinolin, One-pot synthesis, Hantzsch condensation, Zinc oxide