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Organotin(IV) Complexes of 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic Acid: Synthesis, Spectral Characterization and Biological Applications

K. Shahid^a, S. Shahzadi^a, S. Ali^a,*, M.H. Bhatti^b and K.M. Khan^c

^aDepartment of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan
^bDepartment of Chemistry, Allama Iqbal Open University, H-8, Islamabad, Pakistan
^cH.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan

4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid and its complexes with methyl-, n-butyl-, phenyl-, benzyl- and octyl-tin have been synthesized and characterized by elemental analysis and spectral studies. The geometry around the tin atom has been deduced from both solid and solution studies. These complexes were also tested against different bacteria and fungi to determine their toxicity. LD₅₀ data was also calculated using the Brine Shrimp method.

Keywords: Organotin(IV) carboxylates, Spectroscopic characterization, Biological applications