J. Iran. Chem. Soc., Vol. 1, No. 2 December 2004, pp.136~140.
Current location: JICS Archive > Vol. 1 > No. 2 > Articles : 5
A Novel and Efficient Method for the Synthesis of α-Aminonitriles by the Reaction of Aminals with Trimethylsilyl
Cyanide Catalyzed by Iodine
M.R. Saidi* and N. Azizi
Depatment of Chemistry, Sharif University of Technologhy, P. O. Box 11365- 9516 Tehran, Iran
Iodine, was found to be a practical and novel catalyst for the reaction of aminal and trimethylsilyl cyanide under mild and neutral reaction condition to afford the corresponding α-aminonitriles in high yields and short reaction times. Trimethylsilyl iodide derived in situ from elemental iodine and trimethylsillyl cyanide catalyzed this conversion.
Keywords: Trimethylsilyl cyanide, Carbonyl compounds, Iodine, Iminium salt, Aminal
